A Diffuse Interface Model for Cell Blebbing Including Membrane-Cortex Coupling with Linker Dynamics

The aim of this paper is to develop suitable models for the phenomenon cell blebbing, which allow computational predictions mechanical effects including crucial interaction membrane and actin cortex. For sake we resort a two phase-field model that uses diffuse descriptions both cortex, in particular allows description via linker protein densities. Besides detailed modelling discuss some energetic aspects present numerical scheme, carry out several studies. In those demonstrate found experiments can be reproduced, bleb formation by cortex rupture, was not possible previous without dynamics.